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AI in Science: our analysis of AlphaFold 2

18 December 2025

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In December 2025, IGL published the impact report on AlphaFold 2. We present this report as an independent analysis of the scientific impact of AlphaFold 2, and a contribution to the evidence base around AI in science.

We studied the impact of AlphaFold 2 on science, looking at productivity, exploration and applied research outcomes.

Summary report: A high-level overview of our approach and key findings, with conclusions and recommendations.

Full report: A full-length report with a comprehensive literature review, methodology, results and discussion, as well as an extended appendix.

AI in Science: Evidence of impact from AlphaFold 2

The report was also shared in an article by Nature “AlphaFold is five years old — these charts show how it revolutionized science ” and in a blog by Google DeepMind “AlphaFold: Five years of impact“.